Monosomy 7 with severe myelodysplasia developing during imatinib treatment of Philadelphia‐positive chronic myeloid leukemia: Two cases with a different outcome | Zendy

Navarro JoséTomás | Zendy; Feliu Evarist | Zendy; Grau Javier | Zendy; Espinet Blanca | Zendy; Colomer Dolors | Zendy; Ribera JosepMaria | Zendy; Oriol Albert | Zendy; Granada Isabel | Zendy; Juncà Jordi | Zendy; Millá Fuensanta | Zendy

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Monosomy 7 with severe myelodysplasia developing during imatinib treatment of Philadelphia‐positive chronic myeloid leukemia: Two cases with a different outcome

Author(s) -

Navarro JoséTomás,

Feliu Evarist,

Grau Javier,

Espinet Blanca,

Colomer Dolors,

Ribera JosepMaria,

Oriol Albert,

Granada Isabel,

Juncà Jordi,

Millá Fuensanta

Publication year - 2007

Publication title -

american journal of hematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.456

H-Index - 105

eISSN - 1096-8652

pISSN - 0361-8609

DOI - 10.1002/ajh.20859

Subject(s) - imatinib , monosomy , myeloid leukemia , medicine , aneuploidy , trisomy , dysplasia , chromosome 7 (human) , trisomy 8 , leukemia , oncology , cancer research , cytogenetics , chromosome , karyotype , genetics , biology , gene

Chromosomal abnormalities in Ph‐negative metaphases from patients with chronic myeloid leukemia (CML) treated with imatinib have been described in some cases. Trisomy 8 is the most frequent, but monosomy 7 has also been described. However, the association of these chromosomal alterations with myelodysplasia has been scarcely reported. We report the appearance of monosomy 7 in Ph‐negative cells, associated with severe dysplasia, in two patients with CML treated with imatinib, with a different outcome: one with a transient evolution and the other evolving to acute myeloid leukemia. Am. J. Hematol., 2007. © 2007 Wiley‐Liss, Inc.

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