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Monosomy 7 with severe myelodysplasia developing during imatinib treatment of Philadelphia‐positive chronic myeloid leukemia: Two cases with a different outcome
Author(s) -
Navarro JoséTomás,
Feliu Evarist,
Grau Javier,
Espinet Blanca,
Colomer Dolors,
Ribera JosepMaria,
Oriol Albert,
Granada Isabel,
Juncà Jordi,
Millá Fuensanta
Publication year - 2007
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.20859
Subject(s) - imatinib , monosomy , myeloid leukemia , medicine , aneuploidy , trisomy , dysplasia , chromosome 7 (human) , trisomy 8 , leukemia , oncology , cancer research , cytogenetics , chromosome , karyotype , genetics , biology , gene
Chromosomal abnormalities in Ph‐negative metaphases from patients with chronic myeloid leukemia (CML) treated with imatinib have been described in some cases. Trisomy 8 is the most frequent, but monosomy 7 has also been described. However, the association of these chromosomal alterations with myelodysplasia has been scarcely reported. We report the appearance of monosomy 7 in Ph‐negative cells, associated with severe dysplasia, in two patients with CML treated with imatinib, with a different outcome: one with a transient evolution and the other evolving to acute myeloid leukemia. Am. J. Hematol., 2007. © 2007 Wiley‐Liss, Inc.