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Cognitive dysfunction in β‐thalassemia minor
Author(s) -
Nevruz Oral,
Ulas Umit,
Cetin Turker,
Kutukcu Yasar,
Kurekci Ahmet
Publication year - 2007
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.20798
Subject(s) - thalassemia , medicine , cognition , pediatrics , cognitive impairment , minor (academic) , disease , gastroenterology , audiology , psychiatry , political science , law
β‐thalassemia minor is a common, hereditary, and mostly symptomless disease. Previous studies have shown that lower hemoglobin values are associated with poorer cognitive functions. We aimed to evaluate the cognitive function in patients with β‐thalassemia minor. Thirty‐two male subjects with β‐thalassemia minor and 32 sex‐, age‐, and education status‐matched healthy subjects were enrolled in the study. Blood tests and P300 potentials were carried out. P300 potential latency in all patients was significantly longer than those in the control group (337.63 ± 34.89 msec and 310.66 ± 14.30 msec, respectively; t 4.046, P < 0.001). The amplitudes of P300 in patient group were significantly lower than those in the control group (5.19 ± 3.59 μV and 9.81 ± 3.33 μV, respectively; t 5.349, P < 0.001). In this study, we have found that P300 potentials are adversely affected for cognitive functions in patients with β‐thalassemia minor. Am. J. Hematol., 2007. © 2006 Wiley‐Liss, Inc.