Megakaryocytic blast crisis as first presentation of chronic myeloid leukemia | Zendy

Campiotti L. | Zendy; Grandi A.M. | Zendy; Biotti M.G. | Zendy; Ultori C. | Zendy; Solbiati F. | Zendy; Codari R. | Zendy; Venco A. | Zendy

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Megakaryocytic blast crisis as first presentation of chronic myeloid leukemia

Author(s) -

Campiotti L.,

Grandi A.M.,

Biotti M.G.,

Ultori C.,

Solbiati F.,

Codari R.,

Venco A.

Publication year - 2007

Publication title -

american journal of hematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.456

H-Index - 105

eISSN - 1096-8652

pISSN - 0361-8609

DOI - 10.1002/ajh.20797

Subject(s) - medicine , thrombocytosis , myeloid leukemia , blast crisis , imatinib , idarubicin , platelet , apheresis , stroke (engine) , leukocytosis , gastroenterology , cytarabine , mechanical engineering , engineering

We describe an extremely rare case of megakaryocytic blast crisis as first presentation of chronic myeloid leukemia. The patient had a very high platelet count and developed an ischemic stroke with seizures. She was treated with hydroxyurea, platelet apheresis, ARA‐C, and idarubicin in order to obtain a prompt reduction of thrombocytosis and then with imatinib 600 mg/die PO. The therapy induced a complete hematological remission with a resolution of neurological signs within 4 weeks. Am. J. Hematol., 2007. © 2006 Wiley‐Liss, Inc.

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