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Concurrent immune thrombocytopenic purpura and Guillain‐Barre syndrome in a patient with Hashimoto's thyroiditis
Author(s) -
Kohli Rajan Singh,
Bleibel Wissam,
Bleibel Hani
Publication year - 2007
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.20771
Subject(s) - medicine , guillain barre syndrome , thyroiditis , immunology , thrombocytopenic purpura , mucocutaneous zone , genetic predisposition , thyroid , immune system , autoimmune disease , disease , antibody
Abstract Immune thrombocytopenic purpura (ITP), Guillain‐Barre syndrome (GBS), and Hashimoto's thyroiditis (HT) are autoimmune disorders caused by impaired self‐tolerance mechanisms triggered by interaction between genetic and environmental factors. ITP is an immune‐mediated destruction of platelets resulting in mucocutaneous bleeding, GBS is an ascending motor paralysis caused by an inflammatory demyelination of peripheral nerves, and HT is characterized by autoimmune‐mediated destruction of the thyroid gland. The concurrent development of ITP and GBS has only rarely been reported in the literature, and GBS itself rarely occurs with other autoimmune disorders. We present a 21 year‐old patient with known Hashimoto's hypothyroidism that simultaneously developed GBS and ITP after an upper respiratory tract infection. To the best of our knowledge, this is the first reported case of these three autoimmune disorders in the same patient. This points to a possible common genetic predisposition to these disorders. Am. J. Hematol., 2006. © 2006 Wiley‐Liss, Inc.