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Gene frequencies of human platelet alloantigens in Bahraini Arabs
Author(s) -
AlSubaie Abeer M.,
AlAbsi Iman K.,
AlOla Khadija,
Saidi Sarra,
Fawaz Naglaa A.,
Almawi Wassim Y.
Publication year - 2007
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.20769
Subject(s) - allele , genotype , haplotype , biology , genetics , allele frequency , polymorphism (computer science) , immunology , polymerase chain reaction , gene , pathophysiology , endocrinology
Human platelet antigens (HPA) are implicated in the pathophysiology of certain hematological disorders, and as varied distribution of HPA‐1 alleles and genotypes were reported fordifferent countries and ethnic populations, we determined the distribution of HPA‐1, ‐2, ‐3, ‐4, and ‐5 alleles, genotypes and haplotypes for 194 healthy Bahraini subjects by polymerase chain reaction with sequence specific primers. The distribution of the HPA polymorphisms was in Hardy‐Weinberg equilibrium. Allele frequencies of 0.76 and 0.24 (HPA‐1a and ‐1b), 0.77 and 0.23 (HPA‐2a and ‐2b), 0.57 and 0.43 (HPA‐3a and ‐3b), 0.93 and 0.07 (HPA‐4a and ‐4b), and 0.86 and 0.13 (HPA‐5a and ‐5b) were seen. With the exception of HPA‐3a/a (30.4%), the frequencies of homozygous HPA‐1a/a (56.8%), 2a/a (60.1%), 4a/a (87.2%), and 5a/a (75.7%) were higher than those of heterozygous (a/b) or homozygous (b/b) variants. Our results provide basic information for further studies of the HPA system polymorphism, which in turn will be instrumental in understanding and treating immune‐mediated platelet disorders. Am. J. Hematol 2007. © 2006 Wiley‐Liss, Inc.