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Acute myeloid leukemia with T‐cell receptor gamma gene rearrangement occurring in a patient with chronic lymphocytic leukemia: A case report
Author(s) -
Hatoum Hassan A.,
Mahfouz Rami A.R.,
Otrock Zaher K.,
Hudaib AbdelRahman,
Taher Ali T.,
Shamseddine Ali I.
Publication year - 2007
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.20762
Subject(s) - chronic lymphocytic leukemia , gene rearrangement , myeloid leukemia , medicine , leukemia , myeloid , malignancy , cancer research , immunology , pathology , gene , biology , genetics
The association of chronic lymphocytic leukemia (CLL) and acute leukemia, either lymphoid or myeloid is a rare event. Our review of the medical literature revealed only 6 cases of CLL transformation to acute myeloid leukemia (AML) (M0, M1 and M2) with no other associated malignancy. We report a similar case but with occurrence of AML‐M4 associated with normal cytogenetic analysis and molecular testing but with positive T‐cell receptor gamma gene rearrangement rather than the usual Vbeta rearrangement. Am. J. Hematol., 2006. © 2006 Wiley‐Liss, Inc.