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Histone deacetylase inhibitor FK228 is a potent inducer of human fetal hemoglobin
Author(s) -
Cao Hua,
Stamatoyannopoulos George
Publication year - 2006
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.20676
Subject(s) - trichostatin a , histone deacetylase inhibitor , fetal hemoglobin , histone deacetylase , inducer , in vitro , hemoglobin , depsipeptide , chemistry , fetus , pharmacology , biology , microbiology and biotechnology , histone , biochemistry , gene , genetics , pregnancy
We investigated the induction of the human fetal globin gene using five potent histone deacetylase (HDAC) inhibitors: FK‐228, HC‐Toxin, Trichostatin, MS‐275, and Apicidin, using in vitro assays and cultures of primary human erythroblasts. The results showed that FK228 is the most potent inducer of fetal hemoglobin and exhibits its effects in picomolar concentrations. FK228 should be considered as a potential therapeutic for induction of fetal hemoglobin in patients with β chain hemoglobinopathies. Am. J. Hematol., 2006. © 2006 Wiley‐Liss, Inc.