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Hypothermia during the infusion of cryopreserved autologous peripheral stem cell causes electrocardiographical changes: Report of two cases
Author(s) -
Sahin Fahri,
Turk Ugur Onsel,
Yargucu Figen,
Donmez Ayhan,
Cagirgan Seckin
Publication year - 2006
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.20664
Subject(s) - medicine , vomiting , hypothermia , anesthesia , nausea , electrocardiography , transplantation , bradycardia , stem cell , hematopoietic stem cell transplantation , surgery , blood pressure , heart rate , biology , genetics
Currently, autologous peripheral stem cell transplantation used as a therapeutic modality in the treatment of various hematological malignancies is gaining more popularity day by day. In this method, the patient's own peripheral stem cells are collected by a proper method and stored at −80°C until they are reinfused into the patient after being rewarmed in water bath at 37°C. A number of complications have been reported related to reinfusion of the cryopreserved cells into the patient. These may include noncardiovascular complications such as nausea, vomiting, flushing, abdominal pain, chest discomfort, and headache, as well as cardiovascular complications like arrhythmias, hypotension, and hypertension. Hypothermia related to rapid infusion has been reported as the main factor underlying the cardiovascular complications. Electrocardiographic findings of hypothermia include sinusal bradycardia, prolonged QT and PR intervals, widened QRS complexes, and J wave, which is a ECG abnormality characterized by supraventricular and ventricular arrhythmias. We here present two cases of giant J wave caused by hypothermia during infusion of cryopreserved autologous peripheral stem cell that is detected by ECG and regressed after infusion ceased. Am. J. Hematol. 81:627–630, 2006. © Wiley‐Liss, Inc.