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Acute biphenotypic leukemia arising in a patient with essential thrombocythemia
Author(s) -
Wong Gee Chuan,
Lee Lai Heng
Publication year - 2006
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.20651
Subject(s) - medicine , essential thrombocythemia , acute leukemia , induction chemotherapy , immunophenotyping , leukemia , chemotherapy , bone marrow , anagrelide , plateletpheresis , complication , acute megakaryoblastic leukemia , oncology , immunology , gastroenterology , platelet , antigen , apheresis
Acute leukemia is an uncommon complication of patients with essential thrombocythemia (ET). We describe a patient with ET, who transformed to acute biphenotypic leukemia 4 and 1/2 years after initial ET diagnosis. She had received hydroxyurea, anagrelide, and interferon, in different combinations and varying doses, before leukemic transformation. Acute biphenotypic leukemia was confirmed on bone marrow studies and immunophenotyping. Complete remission (CR) was achieved with induction chemotherapy for acute leukemia. This was followed with consolidation chemotherapy and the patient has remained in CR 9 months after initial induction chemotherapy. To our knowledge, this is a rare event of acute biphenotypic leukemic transformation of a patient with ET. Am. J. Hematol. 81:624–626, 2006. © 2006 Wiley‐Liss, Inc.