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Donor cell leukemia in a patient developing 11 months after an allogeneic bone marrow transplantation for chronic myeloid leukemia
Author(s) -
Ataergin Selmin,
Arpaci Fikret,
Cetin Turker,
Guran Sefik,
Yakicier Cengiz,
Beyzadeoglu Murat,
Ozet Ahmet
Publication year - 2006
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.20615
Subject(s) - medicine , leukemia , myeloid leukemia , mitoxantrone , cytarabine , transplantation , chronic leukemia , bone marrow , donor lymphocyte infusion , immunology , acute leukemia , oncology , hematopoietic stem cell transplantation , chemotherapy
A 38‐year‐old female with chronic myeloid leukemia underwent an allogeneic bone marrow transplantation from her full‐matched brother. Eleven months later, she readmitted with an acute leukemia that was shown to be of donor origin. The patient never achieved a remission even after chemotherapies with cytarabine and mitoxantrone, donor lymphocyte infusion, and second allogeneic peripheral blood stem cell transplantation. Donor cell leukemia (DCL) is sometimes misdiagnosed as relapse by clinicians and the real incidence may be higher than expected. Cytogenetic and molecular techniques may be helpful to clarify the issue of the leukemia. The current case is another case of DCL reported in the literature after an allogeneic transplant for a kind of leukemia. Am. J. Hematol. 81:370–373, 2006