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Effects on virological and immunological parameters during CD34 mobilization in HIV patients with lymphoma
Author(s) -
Bortolin Maria Teresa,
Simonelli Cecilia,
Zanussi Stefania,
Pratesi Chiara,
Bidoli Ettore,
Rupolo Maurizio,
Berretta Massimiliano,
Tedeschi Rosamaria,
De Paoli Paolo
Publication year - 2006
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.20610
Subject(s) - mobilization , lymphoma , human immunodeficiency virus (hiv) , medicine , cd34 , chemotherapy , immunology , lentivirus , oncology , virology , viral disease , biology , stem cell , genetics , archaeology , history
The effects of CD34 mobilization with chemotherapy and G‐CSF administration were evaluated in 13 HIV‐positive patients with relapsed lymphomas and low CD4 counts. After mobilization, CD4+ cells increased significantly while HIV‐RNA and integrated HIV‐DNA showed no increases. G‐CSF led to an increase of CD4+ cells with limited effects on HIV replication. Am. J. Hematol., 2006. © 2006 Wiley‐Liss, Inc.