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Successful umbilical cord blood transplantation for severe chronic active Epstein‐Barr virus infection after the double failure of hematopoietic stem cell transplantation
Author(s) -
Ishimura Masataka,
Ohga Shouichi,
Nomura Akihiko,
Toubo Taikai,
Morihana Eiji,
Saito Yusuke,
Nishio Hisanori,
Ide Makoto,
Takada Hidetoshi,
Hara Toshiro
Publication year - 2005
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.20430
Subject(s) - medicine , etoposide , umbilical cord blood transplantation , transplantation , umbilical cord , stem cell , cord blood , total body irradiation , hematopoietic stem cell transplantation , immunology , haematopoiesis , melphalan , gastroenterology , chemotherapy , cyclophosphamide , biology , genetics
An 11‐year‐old boy with severe chronic active Epstein‐Barr virus infection (CAEBV) underwent successful cord blood transplantation (CBT) after consecutive failure of peripheral blood and bone marrow transplantation from his HLA‐mismatched mother. CB cells from an unrelated donor were infused after conditioning with total body irradiation (12 Gy), melphalan (120 mg/m 2 ), and etoposide (600 mg/m 2 ). Complete remission without circulating EBV‐DNA has continued for 15 months after a delayed hematologic recovery. This is the first successful report of CBT for CAEBV. CB may therefore be an alternate source of stem cells for the curative treatment of CAEBV, despite the absence of EBV‐specific cytotoxic T lymphocytes. Am. J. Hematol. 80:207–212, 2005. © 2005 Wiley‐Liss, Inc.