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Partial tandem duplication of MLL gene in acute myeloid leukemia with translocation (11;17)(q23;q12–21)
Author(s) -
Yamamoto Shuichi,
Nishi Masanori,
Taniguchi Kazuto,
Imayoshi Miyoko,
Ogata Yoshiyasu,
Iwanaga Manabu,
Sakai Nana,
Hamasaki Yuhei,
Ishii Eiichi
Publication year - 2005
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.20411
Subject(s) - chromosomal translocation , gene duplication , tandem exon duplication , exon , myeloid leukemia , fusion gene , biology , acute myelomonocytic leukemia , myeloid , gene rearrangement , gene , leukemia , cancer research , monocytic leukemia , haematopoiesis , stem cell , genetics
Translocation 11q23 and MLL gene rearrangements are commonly observed in acute myeloid leukemia (AML) in association with the myelomonocytic or monocytic feature. We describe a case involving a 15‐year‐old patient with AML characterized by leukemic cells exhibiting translocation (11;17)(q23;q12–21) and MLL gene rearrangement. No fusion partner gene of the MLL gene was identified, including RAR α(17q12) or AF17 (17q21); however, a partial tandem duplication of the MLL exon 11/exon 10 was detected in leukemic cells via a 3′RACE method for detection of unknown partner genes. The patient has been in remission for more than 2 years without hematopoietic stem cell transplantation. Am. J. Hematol. 80:46–49, 2005. © 2005 Wiley‐Liss, Inc.