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Factor V G1691A (Leiden) and prothrombin G20210A single‐nucleotide polymorphisms in type 2 diabetes mellitus
Author(s) -
WakimGhorayeb Saria F.,
Keleshian Sose H.,
Timson Georgina,
Finan Ramzi R.,
Najm Pierre,
IraniHakime Noha,
Almawi Wassim Y.
Publication year - 2005
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.20406
Subject(s) - factor v leiden , prothrombin g20210a , medicine , single nucleotide polymorphism , genotype , factor v , gastroenterology , diabetes mellitus , population , type 2 diabetes mellitus , endocrinology , genetics , biology , thrombosis , gene , venous thrombosis , environmental health
Abstract The association of the single nucleotide polymorphisms (SNPs) G1691A in coagulation factor V (FV)‐Leiden and G20210A in prothrombin (PRT) genes with type 2 diabetes mellitus (T2DM) were analyzed in 112 T2DM patients (58 males, 54 females; mean age 55.24 ± 13.5 years) and 249 healthy control subjects (118 males, 131 females; mean age 53.03 ± 13.8 years). No association was found for FV‐Leiden with T2DM, as the frequency of the G/G (82.1% vs. 85.5%), G/A (17.0% vs. 14.1%), and A/A (0.9% vs. 0.4%) genotypes was not different between patients and controls, respectively ( P = 0.644). Similarly, lack of association of PRT G20210A with T2DM was seen among the population studied, and the frequency of the G/G (92.9% vs. 97.2%), G/A (6.3% vs. 2.8%), and A/A (0.9% vs. 0.0%) genotypes was similar among patients and controls, respectively ( P = 0.094). Neither FV‐Leiden nor PRT G20210A was associated with, and no evidence for interactions between these mutations was seen in, T2DM. Am. J. Hematol. 80:84–86, 2005. © 2005 Wiley‐Liss, Inc.