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Evidence for the molecular heterogeneity of sickle cell anemia chromosomes bearing the β S /Benin haplotype
Author(s) -
Patrinos George P.,
Samperi Piera,
lo Nigro Luca,
Kollia Panagoula,
Schiliro Gino,
Papadakis Manoussos N.
Publication year - 2005
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.20400
Subject(s) - haplotype , genetics , biology , sickle cell anemia , bantu languages , sicilian , mutation , cell , allele , gene , linguistics , philosophy
There are at least four distinct African and one Asian chromosomal backgrounds (haplotypes) on which the sickle cell mutation has arisen. Additionally, previous data suggest that the β S /Bantu haplotype is heterogeneous at the molecular level. Here, we report the presence of the A γ −499 T→A variation in sickle cell anemia chromosomes of Sicilian and North African origin bearing the β S /Benin haplotype. Being absent from North American β S /Benin chromosomes, which were studied previously, this variation is indicative for the molecular heterogeneity of the β S /Benin haplotype. Am. J. Hematol. 80:79–80, 2005. © 2005 Wiley‐Liss, Inc.