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Acute myeloid leukemia of donor origin after allogeneic bone marrow transplantation for precursor T‐cell acute lymphoblastic leukemia: Case report and review of the literature
Author(s) -
Reichard Kaaren K.,
Zhang QianYun,
Sanchez Lorraine,
Hozier John,
Viswanatha David,
Foucar Kathryn
Publication year - 2006
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.20389
Subject(s) - myeloid leukemia , leukemia , fluorescence in situ hybridization , transplantation , bone marrow , myeloid , medicine , chromosomal translocation , immunology , karyotype , cytogenetics , cancer research , biology , pathology , gene , genetics , chromosome
We report a case of donor‐derived acute myeloid leukemia (AML) occurring in a 33‐year‐old man after allogeneic bone marrow transplantation (BMT) for precursor T‐cell acute lymphoblastic –leukemia (T‐ALL). The cells for BMT were from his human leukocyte antigen (HLA)‐matched sister. Fluorescence in‐situ hybridization (FISH) analysis showed the AML to be of donor origin (i.e., karyotypically female) with an 11q23 (mixed lineage leukemia (MLL) gene) translocation, while the original T‐ALL exhibited a male karyotype with abnormalities of chromosomes 6, 8, and a t(10;14)(q24;q11.2). Subsequent molecular short tandem repeat studies confirmed the AML to be of donor origin. Donor‐cell leukemia (DCL) after allogeneic BMT is a rare, yet well‐documented, event. Our report presents clinicopathologic information about a case of DCL and a review of the recent literature. Am. J. Hematol. 81:178–185, 2006. © 2006 Wiley‐Liss, Inc.