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Myelofibrosis‐associated massive splenomegaly: A cause of increased intra‐abdominal pressure, pulmonary hypertension, and positional dyspnea
Author(s) -
Ziakas Panayiotis D.,
Voulgarelis Michael,
Felekouras Evagelos,
Anagnostou Dimitra,
Tzelepis George E.
Publication year - 2005
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.20388
Subject(s) - myelofibrosis , medicine , pulmonary hypertension , hypoxemia , blood pressure , hemodynamics , cardiology , surgery , bone marrow
Abstract We describe a patient with myelofibrosis, giant splenomegaly, and pulmonary hypertension related to increased intra‐abdominal pressure. Focusing on alterations in hemodynamic studies, we conclude that in patients with myelofibrosis, dyspnea, and hypoxemia, the measurement of intra‐abdominal pressure should be included in the initial evaluation. It is an inexpensive, non‐invasive diagnostic tool that can provide crucial information about the cause of dyspnea and disclose the pathogenetic link between massive splenomegaly and pulmonary compromise in myelofibrosis. Am. J. Hematol. 80:128–132, 2005. © 2005 Wiley‐Liss, Inc.