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Long‐term remission of blastic natural killer‐cell lymphoma after autologous peripheral blood stem‐cell transplantation
Author(s) -
Yamaguchi Masaki,
Maekawa Mio,
Nakamura Yoshihisa,
Ueda Mikio
Publication year - 2005
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.20383
Subject(s) - medicine , lymphoma , total body irradiation , stem cell , chemotherapy , transplantation , bone marrow , hematopoietic stem cell transplantation , surgery , gastroenterology , cyclophosphamide , biology , genetics
We report here a case of blastic natural killer (NK)‐cell lymphoma treated successfully with autologous peripheral blood stem‐cell transplantation (APBSCT). A 57‐year‐old man had skin tumors and was diagnosed as having blastic NK‐cell lymphoma by tumor biopsy. Skin, lymph nodes, left tonsil, and bone marrow were involved at presentation. Chemotherapy led to complete remission (CR). To sustain CR, the patient underwent high‐dose chemotherapy in combination with 12 Gy of total‐body irradiation (TBI) followed by autologous peripheral blood stem‐cell rescue. He showed rapid recovery of hematopoiesis and could tolerate regimen‐related toxicity after APBSCT. He has maintained long‐term remission for 20 months after APBSCT. From this case, we concluded that APBSCT with preconditioning by TBI‐containing regimens might be a cure‐attaining treatment for disseminated blastic NK‐cell lymphoma and should be considered as a choice of treatment in cases where no suitable donors for allogeneic transplantation are available. Am. J. Hematol. 80:124–127, 2005. © 2005 Wiley‐Liss, Inc.