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Definition of organ involvement and treatment response in immunoglobulin light chain amyloidosis (AL): A consensus opinion from the 10 th International Symposium on Amyloid and Amyloidosis
Author(s) -
Gertz Morie A.,
Comenzo Ray,
Falk Rodney H.,
Fermand Jean Paul,
Hazenberg Bouke P.,
Hawkins Philip N.,
Merlini Giampaolo,
Moreau Philippe,
Ronco Pierre,
Sanchorawala Vaishali,
Sezer Orhan,
Solomon Alan,
Grateau Giles
Publication year - 2005
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.20381
Subject(s) - amyloidosis , al amyloidosis , medicine , immunoglobulin light chain , consensus conference , amyloid (mycology) , intensive care medicine , pathology , immunology , antibody
We undertook this study to develop uniformly accepted criteria for the definition of organ involvement and response for patients on treatment protocols for immunoglobulin light‐chain amyloidosis (AL). A consensus panel was convened comprising 13 specialists actively involved in the treatment of patients with amyloidosis. Institutional criteria were submitted from each, and a consensus was developed defining each organ involved and the criteria for response. Specific criteria have been developed with agreed on definitions of organ and hematologic response as a result of discussions at the 10 th International Symposium on Amyloid and Amyloidosis held in Tours, France, April 2004. These criteria now form the working definition of involvement and response for the purposes of future data collection and reporting. We report criteria that centers can now use to define organ involvement and uniform response criteria for reporting outcomes in patients with light‐chain AL. Am. J. Hematol. 79:319–328, 2005. © 2005 Wiley‐Liss, Inc.