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Meningeal hematopoiesis following radiation myelitis in a hematopoietic stem‐cell transplant recipient
Author(s) -
Sakai Miwa,
Ohashi Kazuteru,
Kobayashi Takeshi,
Yamashita Takuya,
Akiyama Hideki,
Nemoto Tetuo,
Kishida Shuji,
Kamata Noriko,
Sakamaki Hisashi
Publication year - 2005
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.20341
Subject(s) - myelitis , medicine , cyclophosphamide , multiple myeloma , transplantation , extramedullary hematopoiesis , hematopoietic stem cell transplantation , spinal cord , stem cell , pathology , haematopoiesis , surgery , immunology , chemotherapy , biology , psychiatry , genetics
Abstract Extramedullary meningeal hematopoiesis (EMH) represents an uncommon finding after stem‐cell transplantation. We describe the case of an allogeneic bone marrow transplantation (BMT) recipient who developed EMH 1 month after radiation myelitis had been diagnosed. A 39‐year‐old man with multiple myeloma underwent matched unrelated BMT following a myeloablative conditioning regimen of cyclophosphamide and total‐body irradiation (200 cGy × 6). This was followed by delivery of 40 Gy of involved‐field radiation to an extramedullary plasmacytoma compressing the spinal cord. Although transplantation went extremely well, the patient developed radiation myelitis 7 months after transplantation, and EMH ensued 1 month later. Because the patient was not in a disease state known to cause EMH, it is tempting to speculate that radiation‐related neural injuries might cause donor cells to migrate to the central nervous system. Am. J. Hematol. 79:291–293, 2005. © 2005 Wiley‐Liss, Inc.