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Variant lymphoproliferative disorder of granular lymphocytes (LDGL) following Hodgkin lymphoma
Author(s) -
Jenkins Brian Douglas,
Snower Daniel,
Mohamed Anwar,
AlKatib Ayad
Publication year - 2005
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.20312
Subject(s) - lymphocytosis , fluorescence in situ hybridization , asymptomatic , lymphoproliferative disorders , lymphoma , karyotype , medicine , breakpoint , pathology , cd8 , immunology , gastroenterology , immune system , chromosomal translocation , biology , chromosome , gene , genetics
A 41‐year‐old Caucasian female was diagnosed with a CD3 + CD4 + CD8 + variant of lymphoproliferative disorder of granular lymphocytes (LDGL) in the third year of remission following treatment of stage III‐B Hodgkin lymphoma (HL). The patient was asymptomatic at diagnosis, without clinical evidence of immune disorder or recurrence of HL. Diagnosis was made incidentally, secondary to lymphocytosis discovered on a routine follow‐up post HL therapy. Clonal chromosomal abnormalities were seen in 20% of peripheral blood lymphocytes with a karyotype 46, XX, t(2;6;2;11) (p13;q23;q24;q23). The breakpoint on 11q23 is distal to the MLL gene as shown by fluorescence in situ hybridization (FISH) analysis. To our knowledge, this is the first report of variant LDGL in association with HL treatment with documented clonal chromosomal abnormalities. Am. J. Hematol. 79:128–131, 2005. © 2005 Wiley‐Liss, Inc.