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Primary mediastinal B‐cell lymphoma with sclerosis: Report of 11 cases treated with intensified‐CHOP plus radiotherapy
Author(s) -
Siracusano Licia,
Balzarotti Monica,
Magagnoli Massimo,
Castagna Luca,
Rahal Daoud,
Santoro Armando
Publication year - 2005
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.20301
Subject(s) - medicine , chop , radiation therapy , lymphoma , chemotherapy , regimen , retrospective cohort study , rituximab , international prognostic index , surgery , gastroenterology , oncology
Primary mediastinal B‐cell lymphoma (PMBCL) is a clinicopathological entity with aggressive behavior. Retrospective evaluation suggests the need for intensive chemotherapy programs. From 1997 to February 2003, a total of 11 cases of previously untreated PMBCL with sclerosis were treated at our institution with 5 courses of intensified CHOP (ICHOP) regimen and mediastinal irradiation. Three patients were submitted to high‐dose chemotherapy with peripheral‐blood stem‐cell support, followed by radiotherapy, because of intermediate‐risk age‐adjusted International Prognostic Index at diagnosis. After a median follow up of 30 months, all patients but one are in continuous complete remission (CR), and overall survival is 100%. Am. J. Hematol. 78:312–313, 2005. © 2005 Wiley‐Liss, Inc.