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Sickle cell vaso‐occlusive crisis induces the release of circulating serum heat shock protein‐70
Author(s) -
Adewoye Adeboye H.,
Klings Elizabeth S.,
Farber Harrison W.,
Palaima Elizabeth,
Bausero Maria A.,
McMahon Lillian,
Odhiambo Adam,
Surinder Safaya,
Yoder Mark,
Steinberg Martin H.,
Asea Alexzander
Publication year - 2005
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.20292
Subject(s) - vaso occlusive crisis , hsp70 , pathophysiology , shock (circulatory) , heat shock protein , inflammation , medicine , immunology , cell , disease , sickle cell anemia , biology , biochemistry , gene
Inflammation may play an important role in the pathophysiology of sickle cell disease (SCD), and recent studies have identified the 70‐kDa heat shock protein (Hsp70) as an important mediator of inflammatory responses. Here we demonstrate a significant increase in circulating serum Hsp70 level in SCD during vaso‐occlusive crisis (VOC) as compared with baseline steady‐state levels ( P < 0.05) and a significant increase in Hsp70 levels in SCD at baseline compared with normal controls ( P < 0.05). Taken together, these results indicate that circulating serum Hsp70 might be a marker for VOC in SCD. Am. J. Hematol. 78:240–242, 2005. © 2005 Wiley‐Liss, Inc.