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Remission of natural‐killer cell lymphoma of the liver with anti‐hepatitis C therapy
Author(s) -
Armor Jess F.,
Fazili Javid,
Toubia Nagib,
Kern William,
Kamble Rammurti,
KharfanDabaja Mohamed A.
Publication year - 2005
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.20286
Subject(s) - lymphoma , medicine , malignancy , hepatitis c , immunology , neoplasm , hepatitis , natural killer cell , leukemia , pathology , biology , cytotoxicity , biochemistry , in vitro
Non‐Hodgkin lymphomas (NHL) consist of a diverse group of lymphoproliferative neoplasms with unique patterns of biology, behavior, and differing responses to therapy. A rare subtype of malignancy arising from cells of putative natural killer (NK) origin is being recognized as a distinct clinicopathological entity. Viruses including hepatitis C have been reported in association with various types of NHL but not the NK‐cell subtype. We hereby report a unique case of a patient with hepatitis C who developed hepatic NK‐cell lymphoma and chronic NK‐cell leukemia. Interestingly, we observed clinical and radiologic remission of the neoplasm following treatment with anti‐hepatitis C therapy. Am. J. Hematol. 78:212–215, 2005. © 2005 Wiley‐Liss, Inc.