Premium
Long‐term follow‐up of a patient with idiopathic myelofibrosis associated with chromosome 11 and 13 abnormalities
Author(s) -
Toubai Tomomi,
Tanaka Junji,
Higa Toshio,
Ota Shuichi,
Ibata Makoto,
Shono Yusuke,
Mashiko Shinobu,
Miura Yoko,
Umehara Shintaro,
Kahata Kaoru,
Toyoshima Nobuyasu,
Morioka Masanobu,
Asaka Masahiro,
Kasai Masaharu,
Imamura Masahiro
Publication year - 2005
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.20254
Subject(s) - myelofibrosis , trisomy , malignant transformation , aneuploidy , metaplasia , myeloid leukemia , trisomy 8 , medicine , chromosomal abnormality , chromosome abnormality , chromosome , cytogenetics , tetrasomy , myeloid , pathology , karyotype , biology , cancer research , genetics , bone marrow , gene
A case of a leukemic transformation following a 27‐year history of idiopathic myelofibrosis (IMF) is presented. The patient had two chromosomal abnormalities: a deletion of chromosome 13, del 13(q12q14), and a deletion of chromosome 11, del 11(q14q23). This patient's final diagnosis was acute micromegakaryocytic leukemia, and she died 1 month after leukemic transformation with an additional chromosomal abnormality, trisomy 8. IMF with myeloid metaplasia associated with deletion of the long arms of chromosomes 11 and 13 has not been previously reported. We speculate that the leukemic transformation in this patient was associated with chromosomal abnormalities del 11 and trisomy 8. Am. J. Hematol. 78:67–70, 2005. © 2004 Wiley‐Liss, Inc.