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Philadelphia chromosome‐positive acute lymphoblastic leukemia secondary to chemoradiotherapy for Ewing sarcoma. Report of two cases and concise review of the literature
Author(s) -
Snyder David S.,
Stein Anthony S.,
O'Donnell Margaret R.,
Gaal Karl,
Slovak Marilyn L.,
Forman Stephen J.
Publication year - 2005
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.20251
Subject(s) - medicine , oncology , sarcoma , lymphoblastic leukemia , leukemia , radiation therapy , chemotherapy , chemoradiotherapy , population , pediatrics , pathology , environmental health
Survivors of childhood solid tumors including Ewing sarcoma (ES) have an increased risk of secondary malignant neoplasms (SMNs) as a consequence of exposure to chemotherapy and/or radiation (see: Bhatia S, Sklar C. Nat Rev Cancer 2002;2:124–132). The most common hematologic SMNs are myelodysplasia (MDS) and acute myelogenous leukemia (AML). Acute lymphoblastic leukemia (ALL) is uncommon in this patient population, and Philadelphia chromosome positive (Ph + ) ALL in particular, is rare. We report herein two cases of young adult patients who were both diagnosed with Ph + ALL 19 years after successful treatment for ES with combined modality therapy. A review of the relevant literature follows the case reports. Am. J. Hematol. 78:74–78, 2005. © 2004 Wiley‐Liss, Inc.