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Acute promyelocytic leukemia and HIV‐1 infection: Case report and review of the literature
Author(s) -
Kudva Ganesh C.,
Maliekel Kochurani,
Richart John M.,
Batanian Jacqueline R.,
Grosso Leonard E.,
SokolAnderson Marcia,
Petruska Paul J.
Publication year - 2004
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.20192
Subject(s) - acute promyelocytic leukemia , anthracycline , medicine , methotrexate , idarubicin , chromosomal translocation , retinoic acid , chemotherapy , leukemia , mercaptopurine , human immunodeficiency virus (hiv) , immunology , oncology , cytarabine , biology , cancer , biochemistry , breast cancer , gene
We report a 27‐year‐old man with HIV‐1 infection who developed acute promyelocytic leukemia (APL) with a novel complex three‐way chromosomal translocation t(15;16;17). Induction of remission and consolidation with all‐trans ‐retinoic acid (ATRA)‐ and anthracycline‐based chemotherapy was followed by maintenance therapy consisting of ATRA, 6‐mercaptopurine (6‐MP), and methotrexate (MTX). Highly active antiretroviral therapy (HAART) was continued with brief interruptions. He remains in complete remission 40 months after diagnosis. Am. J. Hematol. 77:287–290, 2004. © 2004 Wiley‐Liss, Inc.