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HIV and plasmablastic lymphoma manifesting in sinus, testicles, and bones: A further expansion of the disease spectrum
Author(s) -
Schichman Steven A.,
McClure Rebecca,
Schaefer Robert F.,
Mehta Paulette
Publication year - 2004
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.20190
Subject(s) - plasmablastic lymphoma , medicine , lymphoma , human immunodeficiency virus (hiv) , disease , radiology , pathology , virology
Patients with HIV infection are at increased risk for B‐cell neoplasms and plasma cell dyscrasias. Both B cell and plasma cell tumors tend to be intermediate or high grade and are frequently associated with Epstein‐Barr virus. Patients with HIV infection are also at higher risk of acquiring plasmablastic lymphoma. Until this time, only sinus, oral gastrointestinal, and lung manifestation have been noted. In this report we describe a 41‐year‐old male with HIV infection who developed multiple pleomorphic, extramedullary plasmablastic lymphomas associated with Epstein‐Barr virus. We review the clinical and immunological features of his malignancy and thereby expand the spectrum of disease to include additional sites (bones, testicles) not previously reported. Am. J. Hematol. 77:291–295, 2004. Published 2004 Wiley‐Liss, Inc. †