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Rapid irreversible encephalopathy associated with anti‐D immune globulin treatment for idiopathic thrombocytopenic purpura
Author(s) -
Christopher Kenneth,
Horkan Clare,
Barb Ilie T.,
Arbelaez Christian,
Hodgdon Travis A.,
Yodice Paul C.
Publication year - 2004
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.20189
Subject(s) - medicine , thrombocytopenic purpura , hemolysis , immune system , thrombotic thrombocytopenic purpura , encephalopathy , immunology , gastroenterology , platelet
Intravenous Rho (D) immune globulin (IV RhIG, WinRho SDF) has been shown to be a safe treatment for idiopathic thrombocytopenic purpura (ITP). Common side effects of IV RhIG include mild hemolysis, febrile reaction, and headache. Significant hemolysis with renal impairment following IV RhIG has been reported. We report a case of irreversible encephalopathy 48 hr following an infusion of IV RhIG for treatment of ITP. Am. J. Hematol. 77:299–302, 2004. © 2004 Wiley‐Liss, Inc.