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Squamous cell carcinoma of the tongue complicating chronic oral mucosal graft‐versus‐host disease after allogeneic hematopoietic stem cell transplantation
Author(s) -
Szeto Ching H.,
Shek Tony W.H.,
Lie Albert K.W.,
Au Wing Y.,
Yuen Anthony P.W.,
Kwong Yok L.
Publication year - 2004
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.20160
Subject(s) - medicine , hematopoietic stem cell transplantation , tongue , graft versus host disease , transplantation , myeloid leukemia , disease , stem cell , chronic leukemia , pathology , oral mucosa , leukemia , dysplasia , immunology , acute leukemia , biology , genetics
Two patients underwent allogeneic hematopoietic stem cell transplantation (HSCT) for acute myeloid leukemia. Chronic graft‐versus‐host disease (GVHD) developed, with persistent symptomatic oral lesions. At 2 and 6 years post‐HSCT, both patients developed squamous cell carcinoma (SCC) of the tongue in areas previously involved by chronic GVHD. None had any known risk factor for SCC. Histologically, moderate to severe dysplasia was present in noncancerous oral mucosa. Oral SCC is rarely described after HSCT, and a review of the reported cases showed chronic GVHD to be a common risk, suggesting that the chronic inflammation associated with GVHD might be of pathogenetic significance. Am. J. Hematol. 77:200–202, 2004. © 2004 Wiley‐Liss, Inc.