Premium
Practical approach to the diagnosis and management of thrombocytopenia associated with tirofiban treatment
Author(s) -
Mulot Agnès,
Moulin Frédéric,
FohlenWalter Anne,
Angioi Michael,
Sghaier Mohammed,
Carteaux JeanPierre,
Lecompte Thomas,
de Maistre Emmanuel
Publication year - 2004
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.20149
Subject(s) - tirofiban , medicine , intensive care medicine , percutaneous coronary intervention , myocardial infarction
Anti‐GPIIb/IIIa associated thrombocytopenia has been reported in most large trials, but very little data is available regarding tirofiban. We report three cases of thrombocytopenia, most likely attributed to tirofiban (two moderate and one severe). For each patient, laboratory investigation has allowed us to exclude another cause of thrombocytopenia, particularly heparin‐induced thrombocytopenia. Platelet count recovery could be earlier with tirofiban than with abciximab. Some suggestions are proposed for practical management of these patients with persistent thrombotic risk, who are sometimes candidates for cardiopulmonary bypass surgery. Am. J. Hematol. 77:67–71, 2004. © 2004 Wiley‐Liss, Inc.