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Hydrops fetalis associated with homozygosity for hemoglobin Taybe (α 38/39 THR deletion) in newborn triplets
Author(s) -
Ar Shmuel,
Tamary Hannah,
Dgany Orly,
Litmanovitz Ita,
Regev Rivka,
Bauer Sofia,
Dolfin Tzipora,
Yacobovich Joanne,
Wolach Baruch,
Jaber Lutfi
Publication year - 2004
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.20094
Subject(s) - hydrops fetalis , hemoglobinopathy , medicine , hemoglobin , hemolytic anemia , anemia , fetus , pediatrics , obstetrics , pregnancy , genetics , biology
Hemoglobin Taybe is an unstable α‐chain hemoglobin variant caused by a deletion of a threonine residue at codon 38 or 39 of the α‐1 globin chain. We describe preterm infant triplets born with hydrops fetalis and anemia who were found by DNA analysis to be homozygous for hemoglobin Taybe. All three infants developed intrauterine hemolytic anemia, which subsequently led to hydrops fetalis. To the best of our knowledge, this is the first description of hydrops fetalis associated with this hemoglobinopathy. We suggest that hemoglobin Taybe be considered in the differential diagnosis of hydrops fetalis and that known affected fetuses be carefully followed both antenatally and postnatally. Am. J. Hematol. 76:263–266, 2004. © 2004 Wiley‐Liss, Inc.