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Hemostatic markers and the sepsis‐related organ failure assessment score in patients with disseminated intravascular coagulation in an intensive care unit
Author(s) -
Okabayashi Kazuhiro,
Wada Hideo,
Ohta Syunsuke,
Shiku Hirosi,
Nobori Tsutomu,
Maruyama Kazuo
Publication year - 2004
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.20089
Subject(s) - disseminated intravascular coagulation , sofa score , medicine , sepsis , intensive care unit , antithrombin , coagulopathy , gastroenterology , heparin
We investigated the correlation between disseminated intravascular coagulation (DIC) score and hemostatic parameters and sepsis‐related organ failure assessment (SOFA) score with clinical outcome of patients with DIC in an intensive care unit (ICU). The SOFA score was markedly elevated in patients with DIC relative to patients without DIC and significantly higher in non‐survivors than in survivors. Abnormalities in almost all hemostatic parameters were significant in patients with DIC, but there was no significant difference in almost all hemostatic parameters between survivors and non‐survivors. However, plasma antithrombin (AT) levels were significantly lower in non‐survivors than in survivors. Soluble fibrin (SF) and tissue type plasminogen activator (tPA)–plasminogen activator inhibitor‐I (PAI‐I) complex correlated significantly with the SOFA score, whereas AT levels correlated significantly and negatively with the SOFA score. We conclude that the SOFA score is useful for predicting outcome in DIC patients in the ICU, and that hemostatic parameters, especially plasma AT levels, are also useful markers for organ failure and clinical outcome. Am. J. Hematol. 76:225–229, 2004. © 2004 Wiley‐Liss, Inc.