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Hemophagocytic syndrome as a presenting sign of transformation of smoldering to acute adult T‐cell leukemia/lymphoma: Efficacy of anti‐retroviral and interferon therapy
Author(s) -
Aouba Achille,
Lambotte Olivier,
Vasiliu Viorel,
Divine Marine,
Valensi Françoise,
Varet Bruno,
Bazarbachi Ali,
Hermine Olivier
Publication year - 2004
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.20065
Subject(s) - medicine , lymphoma , leukemia , lymphocytosis , tumor lysis syndrome , immunology , adult t cell leukemia/lymphoma , chemotherapy , t cell leukemia
A 55‐year‐old Caribbean woman with a 6‐year history of smoldering adult T‐cell leukemia/lymphoma presented with clinical and biological symptoms of hemophagocytic syndrome. An extensive search for infectious diseases was negative. A lymph node biopsy showing large T‐cell lymphoma (CD4 − , CD25 + ) and findings of high LDH count and severe lymphocytosis led to the diagnosis of acute adult T‐cell leukemia/lymphoma. Anti‐retroviral therapy combining zidovudine, lamivudine, and interferon‐α was started, resulting in rapid control of both hemophagocytic syndrome and symptoms of acute adult T‐cell leukemia/lymphoma. Thus, we propose that adult T‐cell leukemia/lymphoma must be added to the spectrum of etiologies of hemophagocytic syndrome. Am. J. Hematol. 76:187–189, 2004. © 2004 Wiley‐Liss, Inc.