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Thalidomide in POEMS syndrome: Case report
Author(s) -
Sinisalo Marjatta,
Hietaharju Aki,
Sauranen Jukka,
Wirta Ole
Publication year - 2004
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.20051
Subject(s) - poems syndrome , organomegaly , thalidomide , medicine , polyneuropathy , ascites , lenalidomide , gastroenterology , pathology , dermatology , immunology , multiple myeloma
We report a patient with incapacitating POEMS syndrome characterized by serum monoclonal protein, polyneuropathy, organomegaly, endocrinopathy, mesangiocapillary glomerulonephritis, massive ascites formation, and pulmonary hypertension. A dramatic improvement in the clinical condition occurred after administration of thalidomide, a drug with known anti‐angiogenetic, anti‐proliferative, and anti‐cytokine properties. Am. J. Hematol. 76:66–68, 2004. © 2004 Wiley‐Liss, Inc.