Premium
Thromboembolic complications after splenectomy for hematologic diseases
Author(s) -
Mohren Martin,
Markmann Ilka,
Dworschak Ulrike,
Franke Astrid,
Maas Christian,
Mewes Sabine,
Weiss Günter,
JentschUllrich Kathleen
Publication year - 2004
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.20018
Subject(s) - medicine , splenectomy , pulmonary embolism , thrombosis , portal vein thrombosis , incidence (geometry) , deep vein , surgery , autoimmune hemolytic anemia , anemia , spleen , physics , optics
Thromboembolic complications following splenectomy for hematologic diseases occur in up to 10% of patients and may range from portal vein thrombosis (PVT) to pulmonary embolism (PE) and deep vein thrombosis (DVT). Up to now there exist no recommendations for the duration and intensity of prophylactic anticoagulation, which usually follows local institutional protocols. We report on three consecutive patients with severe portal vein thrombosis and/or pulmonary embolism—one with fatal outcome—7 to 35 days after splenectomy for autoimmune hemolytic anemia, immunothrombocytopenia, and indolent lymphoma, respectively. Incidence and pathophysiology of thromboembolic events (TE) in this patient group as well as prophylactic anticoagulation will be discussed, including a review of the current literature on this topic. Am. J. Hematol. 76:143–147, 2004. © 2004 Wiley‐Liss, Inc.