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Unrelated peripheral blood and cord blood hematopoietic stem cell transplants for thalassemia major
Author(s) -
Tan Patrick HuatChye,
Hwang William Ying Khee,
Goh Yeow Tee,
Tan Poh Lin,
Koh Liang Piu,
Tan Cheng Hoe,
Quah Thuan Chong
Publication year - 2004
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.20015
Subject(s) - thalassemia , medicine , cord blood , stem cell , hematopoietic stem cell transplantation , bone marrow , haematopoiesis , hematopoietic stem cell , peripheral blood , transplantation , immunology , biology , genetics
Allogeneic hematopoietic stem cell transplantation is currently the only curative treatment available for thalassemia major. While sibling donors are usually used, unrelated bone marrow transplants have also recently been found to be successful. In this report of two patients, we show that, besides using unrelated bone marrow, peripheral blood stem cell and cord blood transplantations from unrelated donors are viable options. We believe a significant contributory factor in both our cases was the large cell dose used. Am. J. Hematol. 75:209–212, 2004. © 2004 Wiley‐Liss, Inc.