Premium
Rheological determinants in patients with Gaucher disease and internal inflammation
Author(s) -
Zimran Ari,
Bashkin Amir,
Elstein Deborah,
Rudensky Bernard,
Rotstein Rivka,
Rozenblat Meirav,
Mardi Tamar,
Zeltser David,
Deutsch Varda,
Shapira Itzhak,
Berliner Shlomo
Publication year - 2004
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.20011
Subject(s) - erythrocyte sedimentation rate , erythrocyte aggregation , fibrinogen , subclinical infection , medicine , inflammation , leukocytosis , gastroenterology , pathology , immunology , endocrinology
The purpose of this study was to determine whether the inflammatory response in patients with Gaucher disease (GD) is accompanied by enhanced adhesiveness/aggregation of both red and white blood cells. Sixty patients with GD and matched controls were included. The degree of erythrocyte and leukocyte adhesiveness/aggregation was determined by using a simple slide test and image analysis. Patients with GD had significantly elevated concentrations of fibrinogen (328 vs. 262 mg/dl, P < 0.0001) and accelerated erythrocyte sedimentation rates (27 vs. 13 mm/H, P < 0.005). This was accompanied by a significantly enhanced degree of erythrocyte (75 vs. 85, P < 0.0001) and leukocyte (3.5 vs. 1.3, P < 0.002) adhesiveness/aggregation. The low‐grade, smoldering, and subclinical internal inflammation in individuals with GD is accompanied by an increased degree of erythrocyte and leukocyte adhesiveness/aggregation. These findings might have rheological consequences in terms of microcirculatory slow flow and tissue hypoxemia. Am. J. Hematol. 75:190–194, 2004. © 2004 Wiley‐Liss, Inc.