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Direct demonstration of iron in a term placenta in two cases of β‐thalassemia
Author(s) -
Artico M.,
Ballati G.,
Bosco S.,
Cantarelli D.,
Nagar G.,
Grosso A.,
Leali F.M. Tranquilli,
Cavallotti C.
Publication year - 2004
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.20005
Subject(s) - thalassemia , placenta , beta thalassemia , pregnancy , intracellular , cytoplasm , iron deficiency , basal (medicine) , medicine , fetus , andrology , pathology , biology , obstetrics , physiology , chemistry , biochemistry , anemia , genetics , insulin
The aim of this study was to quantify iron in the placentas at the end of pregnancy in two patients suffering from β‐thalassemia and compare the data to that recorded from the placentas of healthy women. Iron was quantified in placental specimens taken after the delivery. The specimens were subjected to chemical treatments in order to remove extracellular iron and leave the intracellular iron intact. After coloration, each specimen was subjected to quantitative analysis of images in order to identify and quantify iron. Our results demonstrated that in β‐thalassemia there is an accumulation of iron in the outer basal cytoplasm of the epithelial cells of placental cotyledons. Am. J. Hematol. 75:241–242, 2004. © 2004 Wiley‐Liss, Inc.