Premium
Diverse clinical outcomes of eosinophilic patients with T‐cell receptor gene rearrangements: The emerging diagnostic importance of molecular genetics testing
Author(s) -
Butterfield Joseph H.
Publication year - 2001
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.1157
Subject(s) - eosinophilia , hypereosinophilic syndrome , eosinophilic , cd8 , gene rearrangement , biology , gene , immunology , molecular genetics , receptor , genetics , immune system
Abnormal clones of clusters of differentiation (CD)3 − CD4 + or CD3 + CD4 − CD8 − phenotypically abnormal lymphocytes have been identified in some patients who have the idiopathic hypereosinophilic syndrome. This report illustrates the disparate clinical courses of six eosinophilic patients with evidence of abnormal T‐cell clones based on the finding of a T‐cell receptor gene rearrangement. The data suggest that molecular genetics testing for T‐cell receptor gene rearrangements should be included in the routine work‐up of patients with idiopathic eosinophilia. Am. J. Hematol. 68:81–86, 2001. © 2001 Wiley‐Liss, Inc.