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Relationships between thrombohemorrhagic complications and platelet function in patients with essential thrombocythaemia
Author(s) -
RaszejaSpecht Anna,
Skibowska Anna,
Bieniaszewska Maria,
Szutowicz Andrzej
Publication year - 2001
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.1145
Subject(s) - platelet , medicine , thrombocytosis , mean platelet volume , platelet factor 4 , platelet aggregation , gastroenterology , beta thromboglobulin
Three subgroups have been distinguished in essential thrombocythaemia (ET) patients, on the basis of clinical and laboratory findings. ET patients with bleeding incidents had smaller platelet volume, lower concentrations of β‐thromboglobulin and platelet factor 4 in their plasma, 10%, 26%, and 26% lower compared to patients without complications, respectively. ATP secretion from platelets of bleeders, clotters, and “no‐complications” ET patients was found to be 75%, 36%, and 45%, respectively, lower than in healthy people. Spontaneous platelet aggregation appeared to be normal in about 90% of ET patients with no complications and in all bleeders but only in 35% patients with clotting incidents. All bleeders had abnormal agonist‐evoked aggregation assays. Among remaining ET patients 30%–60% displayed normal values of different evoked aggregation tests. Thus, clinically distinguished group of bleeding ET patients may be differentiated from other subgroups on the basis of laboratory findings. Am. J. Hematol. 68:32–36, 2001. © 2001 Wiley‐Liss, Inc.