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Report of three cases of circulating heparin‐like anticoagulants
Author(s) -
Llamas Pilar,
Outeiriño Julio,
Espinoza José,
Santos Ana B.,
Román Alejandro,
Tomás José F.
Publication year - 2001
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.1126
Subject(s) - heparin , medicine , anticoagulant , intensive care medicine
Abstract Clinically significant endogenous circulating heparin‐like anticoagulant activity has been associated with hematological malignancies, liver damage, and other pathological conditions. The source of high plasma concentrations of endogenous heparin‐like anticoagulants is poorly understood. We report three cases of circulating heparin‐like anticoagulants in three patients with hematological malignancies: CLL, multiple myeloma, and T‐prolymphocytic leukemia. The severity of bleeding in our patients ranged from severe epistaxis and deep‐site hematoma to bleeding of biopsy site and occasional ecchymosis. Am. J. Hematol. 67:256–258, 2001. © 2001 Wiley‐Liss, Inc.