Premium
Extreme warfarin sensitivity in siblings associated with multiple cytochrome P450 polymorphisms
Author(s) -
Tabrizi Arash Rafii,
McGrath Sean D.,
Blinder Morey A.,
Buchman Timothy G.,
Zehnbauer Barbara A.,
Freeman Bradley D.
Publication year - 2001
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.1094
Subject(s) - warfarin , cytochrome p450 , cyp2c9 , pharmacogenetics , genotype , medicine , biology , genetics , pharmacology , gene , metabolism , atrial fibrillation
Warfarin use is complicated by an erratic dose response. Warfarin is metabolized by two distinct subfamilies of the cytochrome P450 (CYP) complex. We describe two siblings with extreme sensitivity to warfarin who share an unusual CYP genotype. These individuals illustrate both the importance of genetics in influencing the metabolism of warfarin as well as the potential utility of genetic testing as a guide to prescribing this medication. Am. J. Hematol. 67:144–146, 2001. © 2001 Wiley‐Liss, Inc.