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Clinical and pathologic findings in 52 consecutively autopsied cases with multiple myeloma
Author(s) -
Oshima Kumi,
Kanda Yoshinobu,
Nannya Yasuhito,
Kaneko Makoto,
Hamaki Tamae,
Suguro Miyuki,
Yamamoto Rie,
Chizuka Aki,
Matsuyama Tomohiro,
Takezako Naoki,
Miwa Akiyoshi,
Togawa Atsushi,
Niino Hihumi,
Nasu Michiyo,
Saito Kiyoshi,
Morita Toyohiko
Publication year - 2001
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.1067
Subject(s) - medicine , multiple myeloma , autopsy , pneumonia , amyloidosis , cause of death , pathology , disease
We studied clinical features and pathologic findings in 52 consecutively autopsied patients with multiple myeloma in our center between 1979 and 1998. Distant extraosseous involvement was found in 33 patients (63.5%). Thirty‐one patients (59.6%) were proven to have infection at autopsy, among which pneumonia was most common site of infection. Amyloidosis was shown in 8 patients. Second malignancies were observed in 4 cases. The three major causes of death were hemorrhage, infection, and renal failure, which accounted for death in approximately 70% of the patients. Advances in the anticancer and antimicrobial chemotherapies might have decreased deaths due to myeloma itself or infection. Am. J. Hematol. 67:1–5, 2001. © 2001 Wiley‐Liss, Inc.