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Acquired amegakaryocytic thrombocytopenia purpura and eosinophilic fasciitis: A long relapsing and remitting course
Author(s) -
Chaudhary Uzair B.,
Eberwine Stephen F.,
Hege Kristen M.
Publication year - 2004
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.10475
Subject(s) - medicine , eosinophilic fasciitis , purpura (gastropod) , bone marrow , disease , immunology , dosing , etiology , eosinophilia , pathology , biology , ecology
Acquired amegakaryocytic thrombocytopenia purpura (AATP) is a rare disorder of unclear etiology characterized by severe thrombocytopenia, preservation of erythroid and myeloid cell lines, and absence of megakaryocytes in the bone marrow. We report herein a patient who developed eosinophilic fasciitis preceding a diagnosis of AATP. Longitudinal follow‐up and treatment of this individual show a relapsing and remitting disease course which appears closely related to the dosing of cyclosporine. Later in the treatment course, dosing of anti‐thymocyte globulin (ATG) appeared to have important beneficial contributions in the management of this patient's disease. Am. J. Hematol. 75:146–150, 2004. © 2004 Wiley‐Liss, Inc.