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Transfusion‐related acute lung injury (TRALI) following allogeneic stem cell transplant for acute myeloid leukemia
Author(s) -
Ganguly Siddhartha,
Carrum George,
Nizzi Frank,
Heslop Helen E.,
Popat Uday
Publication year - 2004
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.10452
Subject(s) - medicine , transfusion related acute lung injury , hypoxemia , complication , myeloid leukemia , platelet transfusion , diffuse alveolar damage , acute leukemia , blood product , hematopoietic stem cell transplantation , granulocyte , lung , platelet , transplantation , pulmonary edema , leukemia , immunology , surgery , acute respiratory distress
Transfusion‐related acute lung injury (TRALI) is a serious complication of transfusion characterized by dyspnea, hypoxemia, hypotension, fever, and bilateral pulmonary infiltrates. Although the frequency is estimated at 1/1,120 to 1/5,000 transfusions, few cases have been reported after hematopoietic stem cell transplant. We report a case occurring in an allogeneic transplant recipient who developed acute respiratory distress and bilateral pulmonary infiltrates 2 hr after a platelet transfusion due to the presence of anti granulocyte antibody HNA‐3a in the product. As there is a wide differential diagnosis for pulmonary infiltrates developing post transplant, TRALI may be under‐recognized and should be considered in this setting. Am. J. Hematol. 75:48–51, 2004. © 2003 Wiley‐Liss, Inc.
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