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Immune thrombocytopenic purpura associated with Brucella and Toxoplasma infections
Author(s) -
Gürkan Emel,
Başlamişli Fikri,
Güvenç Birol,
Bozkurt Berna,
Ünsal Çağatay
Publication year - 2003
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.10382
Subject(s) - thrombocytopenic purpura , immunology , immune system , brucella , medicine , brucellosis , virology
Bacterial and protozoal infections can cause thrombocytopenia and may mimic idiopathic thrombocytopenic purpura (ITP). Brucella species and Toxoplasma are among the infectious agents with protean clinical manifestations which may induce immune thrombocytopenia. In rare cases, thrombocytopenia can be severe and may result bleeding into the skin and from mucosal sites. Prompt recognition of this complication and aggressive therapy are essential, since the mortality associated with bleeding into the central nervous system is high. We report two patients with complaints of severe epistaxis and thrombocytopenia associated with brucellosis and toxoplasmosis. Thrombocytopenic purpura in these cases responded well to the high‐dose corticosteroid treatment with platelet recovery within 2–3 days. For cases with infection‐induced immune thrombocytopenic purpura, short‐term high‐dose corticosteroids may be applied as an urgent therapy without worsening of the clinical condition. Am. J. Hematol. 74:52–54, 2003. © 2003 Wiley‐Liss, Inc.