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Hypereosinophilia associated with cardiac rhabdomyosarcoma
Author(s) -
Lo Re Vincent,
Fox Kevin R.,
Ferrari Victor A.,
Scott Craig H.,
Kossev Plamen M.,
Kostman Jay R.
Publication year - 2003
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.10373
Subject(s) - hypereosinophilia , malignancy , medicine , etiology , rhabdomyosarcoma , eosinophil , pathology , eosinophilia , sarcoma , asthma
Hypereosinophilia, defined as an absolute eosinophil count exceeding 1,500/mm 3 , is caused by a limited number of disorders. Its association with malignancy is a rare occurrence that typically denotes extensive metastasis and a poor prognosis. Several theories have been proposed to explain the hypereosinophilia associated with malignancy, focusing on the production of eosinophilopoietic cytokines by tumors. We describe a patient with hypereosinophilia associated with a cardiac rhabdomyosarcoma, review the etiologies of hypereosinophilia, and discuss the possible mechanisms. Am. J. Hematol. 74:64–67, 2003. © 2003 Wiley‐Liss, Inc.