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Thrombotic thrombocytopenic purpura associated with a prolactin‐producing pituitary adenoma
Author(s) -
Kovacs Kalman,
Garvey M. Bernadette
Publication year - 2003
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.10366
Subject(s) - medicine , thrombotic thrombocytopenic purpura , galactorrhea , pituitary adenoma , autopsy , prolactin , von willebrand factor , schistocyte , pituitary gland , pathology , adenoma , pituitary tumors , platelet , hormone
We report here the case of a 44‐year‐old woman with thrombocytopenia, anemia, convulsions, hyperprolactinemia, and galactorrhea. The patient died of cardiac failure. Autopsy revealed PAS‐positive and von Willebrand factor‐positive microthrombi in the arterioles and capillaries of many organs, mainly in the heart and brain, confirming the clinical diagnosis of thrombotic thrombocytopenic purpura. In the pituitary, a prolactin‐producing adenoma was identified. To our knowledge, thrombotic thrombocytopenic purpura accompanied by a prolactin‐secreting pituitary adenoma has not yet been described. The question of whether the association between the vascular changes and the pituitary adenoma is incidental or causal cannot be answered. Further studies are required to determine whether prolactin released from the pituitary tumor in excess played a role in the formation of microthrombi causing multiple organ failure and the demise of the patient. Am. J. Hematol. 74:55–59, 2003. © 2003 Wiley‐Liss, Inc.