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Pure red cell aplasia in a Sjögren's syndrome/lupus erythematosus overlap patient
Author(s) -
Mavragani Clio P.,
Vlachaki Eythymia,
Voulgarelis Michalis
Publication year - 2003
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.10302
Subject(s) - medicine , pure red cell aplasia , asymptomatic , immunosuppression , immunology , lupus erythematosus , anemia , bone marrow , aplasia , erythropoiesis , systemic lupus erythematosus , disease , antibody , pathology
Hematological complications of systemic lupus erythematosus usually include anemia of chronic disease and peripheral destruction of blood cells. We describe the case of a young woman with Sjögren's syndrome'lupus erythematosus overlap, mother of infant with congenital heart block, complicated by pure red cell aplasia. The patient was asymptomatic until the onset of severe anemia. A serum inhibitor of erythropoiesis was detected before the onset of immunosuppression. Bone marrow examination showed a low CD4:CD8 ratio, an immune defect possibly linked with the unrestrained production of antibodies against erythroid progenitor cells. Am. J. Hematol. 72:259–262, 2003. © 2003 Wiley‐Liss, Inc.